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RP PSA Failure

"Prostate cancer recurrence generally occurs in 30% to 50% of patients within 10 years after radical prostatectomy and is first indicated by an increased serum value of prostate specific antigen (PSA)."

Source: (Scattoni V, Montorsi F, Picchio M, Fazio F, Roscigno M, Salonia A, Rigatti P: Techniques for Detecting Recurrent Prostate Cancer after Radical Prostatectomy. The American Journal of Urology Review. November 2004, Vol. 2, No. 11, page 555 � 560.)

Additional Reference for prostate cancer recurrence after radical prostatecomy:

Han M, Partin AW, Zahurak M, et al. Biochemical (prostate specific antigen) recurrence probability following radical prostatectomy for clinically localized prostate cancer. Journal of Urology. 2003;169:517-523.

What PSA value indicates a recurrence of prostate cancer after radical prostatectomy?

Studies have used the following PSA values to indicate recurrence of prostate cancer after surgery:

>0.1 ng/mL
> 0.2 ng/mL
> 0.4 ng/mL
> 0.5 ng/mL

Some studies have used two consecutive values of greater than or equal to 0.2 ng/mL, and as of this writing 0.2 ng/mL seems to have some consensus as the value to use for indicating a biochemical recurrence of prostate cancer after the radical prostatectomy.

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© November 27, 2004, Bradley Hennenfent, MD

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