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PSA Less than 4 in the setting of Prostate Cancer
Let's summarize a study:2,950 men (ages 62 to 91) never had a PSA over 4.0 ng per milliliter
after being in a study for 7 years.
449 (15.2%) had prostate cancer when
a biopsy was done.
67 (14.9%) of the 449 men with cancer had with a Gleason
score of 7 or higher.
Interestingly, the prevalence of prostate cancer in men with a PSA level up to 0.5 ng/milliliter was 6.6 percent.
The prevalence of prostate cancer with a PSA level up to 1.0 ng/milliliter was 16.7 percent.
This study shows how prevalent prostate cancer is as men get older and also goes to show that men die with prostate cancer and not from it, as prostate cancer is so often small and slow-growing in older men. This is why you really have to know the odds when it comes to prostate cancer treatment.
Reference:
Thompson IM, Pauler DK, Goodman PJ, Tangen CM, Lucia MS, Parnes HL,
Minasian LM, Ford LG, Lippman SM, Crawford ED, Crowley JJ, Coltman
CA Jr: Prevalence of prostate cancer among men with a prostate-specific
antigen level < or =4.0 ng per milliliter. N Engl J Med. 2004
May 27;350(22):2239-46.
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By Bradley Hennenfent, MDNovember 21, 2004
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